Protein Details: Small conductance calcium-activated potassium channel protein 1

Protein ID

ICDB_Pro_1477

Protein Name

Small conductance calcium-activated potassium channel protein 1

Gene Name

Kcnn1; Sk1

Organism

Mus musculus (Mouse)

Length

537 amino acids

AlphaFoldDB

AF-Q9EQR3-F1-model_v4.pdb

Function

Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization

Sequence

MSSHSHNGSVGQPLGSGPGFLGWEPVDPEAGRPLQPTQGPGLQMVAKGQPVRLSPGGSRGHPQEQEEEEEEEEEEDKTGSGKPPTVSHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLCSFALKCLISLSTVILLGLVILYHAREIQLFLVDNGADDWRIAMTWERVSLISLELVVCAIHPVPGHYRFTWTARLAFSLVPSAAEADLDVLLSIPMFLRLYLLARVMLLHSRIFTDASSRSIGALNRVTFNTRFVTKTLMTICPGTVLLVFSVSSWIVAAWTVRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQGRVRKHQRKFLQAIHQAQKLRSVKIEQGKVNDQANTLAELAKAQSIAYEVVSELQAQQEELEARLAALESRLDVLGASLQALPGLIAQAICPLPPPWPGPGHLATATHSPQSHWLPTMGSDCG

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Highest expression in brain and liver with lower levels in heart; testis; kidney and colon. In colon; detected in smooth muscle cells. Expressed in atrial and ventricular myocytes with higher levels in atrial myocytes.

DOI ID

10.1016/s0167-4781(01)00166-x; 10.1152/ajpgi.2001.281.4.g964; 10.1152/ajpheart.00534.2005; 10.1101/gr.2596504

RefSeq

NP_115773.2; XP_006509870.1; XP_006509871.1